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ForumsSide Effects & ManagementConstipation on GLP-1: pathophysiology and fiber protocol — anyone have experience?

Constipation on GLP-1: pathophysiology and fiber protocol — anyone have experience?

SallyK_inj Tue, Jul 9, 2024 at 4:00 AM 26 replies 2,000 viewsPage 1 of 6
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SallyK_inj
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Jul 9, 2024 at 4:00 AM#1

Putting this up for argument rather than for agreement. I have read it twice and I am still not certain what it supports.

The mechanism is slowed transit plus reduced intake, and that combination determines which interventions work. Less food means less bulk, slower motility means more water reabsorbed, and the result is a smaller, drier, slower stool. Insoluble fiber adds bulk to a system that is already moving slowly, which is why it frequently makes things worse. Soluble fiber holds water and is the better first choice, and an osmotic agent works with the mechanism rather than against it.

Where I think it is weakest: the follow-up is short relative to how long people actually take these drugs, so durability is an assumption here rather than a finding.

What I am trying to establish is whether fiber actually helps GLP-1 constipation or whether the evidence is borrowed from a different population. Not looking for reassurance. Looking for the part I have got wrong.

Note on sourcing:
Figures above are from the primary publication rather than the press summary. If a number here disagrees with one you have, post yours and we will work out which of us is reading a secondary source.
6 1amy_econ_NJ, bbq_ray_KC, oliver_london and 3 others
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TirzTom
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Jul 9, 2024 at 5:23 AM#2
SallyK_inj said:
The mechanism is slowed transit plus reduced intake, and that combination determines which interventions work.

Agreeing with SallyK_inj, and the qualification matters more than the agreement. The escalation order that reflects the mechanism: water and salt first, then soluble fiber, then magnesium or an osmotic agent, then a stimulant only briefly and only if the osmotic has failed. Stimulants first is the commonest error and the one most likely to end in a cycle of dependence.

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amsterdam_pete
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Jul 9, 2024 at 6:46 AM#3
SallyK_inj said:
The mechanism is slowed transit plus reduced intake, and that combination determines which interventions work.

Worth saying plainly that not all of this is benign. Severe constipation on delayed gastric emptying has produced obstruction and ileus cases, rarely but genuinely. Pain with vomiting and no bowel movement is not a fiber conversation.

Last edited: Jul 9, 2024 at 12:46 PM
4 24CanadaChris, ZaraB_AL, JakeSmashed95 and 1 other
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sophie_paris
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Jul 9, 2024 at 8:09 AM#4

This one has a reasonably settled answer, so here it is. Fiber trials in this population are thin, and most of what gets quoted is extrapolated from idiopathic constipation in people eating normally. The extrapolation is not unreasonable but it is an extrapolation, and it fails specifically for insoluble fiber at low intake — the case that comes up here most often.

Last edited: Jul 9, 2024 at 1:09 PM
3 23AussieAnna, BethLabQueen, ChrisMacros
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MikeNYC_runner
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Jul 9, 2024 at 4:10 PM#5
TirzTom said:
The escalation order that reflects the mechanism: water and salt first, then soluble fiber, then magnesium or an osmotic agent, then a stimulant only…

Second this.

Last edited: Jul 9, 2024 at 6:10 PM
2 22MASHdoc_SA, GenomicsKate
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