Dr.GutHealth said:

Practical: whatever you change, write down the date and the reason.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

Happy to go further on any of that.

Dr.GutHealth said:

Practical: whatever you change, write down the date and the reason.

No disagreement, though the timescale matters more than the mechanism here. Most of what looks like a difference in kind turns out to be a difference in how long somebody waited.

Dr.GutHealth said:

Practical: whatever you change, write down the date and the reason.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. I will report back once I have actually tried it.

Clinical perspective, offered as context rather than as advice. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

PharmHunterJen said:

It is worth asking what the claim would look like if it were false.

Second this. The detail I would add is minor and it is already implied above.