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Evidence-based GLP-1 & peptide discussion since 2023
ForumsProgress & Lab Results[PREMIUM] 18-month transformation — 12 month update

[PREMIUM] 18-month transformation — 12 month update

rick_sfbay Thu, May 30, 2024 at 3:37 PM 30 replies 2,506 viewsPage 1 of 6
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rick_sfbay
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Jan 2025
San Francisco, CA
May 30, 2024 at 3:37 PM#1

Thirteen weeks at the same dose with no change on the scale, and I have gone from assuming it was the drug to assuming it was me and back several times.

The question I want answered is how to distinguish a genuine plateau from measurement noise and creeping intake, before changing anything.

If the honest answer is that nobody knows, that is a useful answer and I would rather have it.

49 19mike_mealprep, NicoleRaleigh, james_edin and 46 others
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Dr.NateNeph
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May 30, 2024 at 3:43 PM#2
rick_sfbay said:
Thirteen weeks at the same dose with no change on the scale, and I have gone from assuming it was the drug to assuming it was me and back several…

Plateau breaking story with a stall: I stalled at 210 lbs for 7 weeks. Tried everything — calorie cycling, increased exercise, more water. Nothing worked.

What finally broke the plateau: a brief dose increase followed by return to maintenance. Lost 8 lbs in the next 3 weeks. Plateaus are temporary — they always break if you stay consistent.

48 18NauseaFreeNow, SteveThurs, B12Beth and 45 others
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fiona_VT
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May 30, 2024 at 3:49 PM#3
Dr.NateNeph said:
Plateau breaking story with a stall: I stalled at 210 lbs for 7 weeks.

Dr.NateNeph has the substance of this right. The condition it depends on is worth stating. Most reported plateaus are not plateaus. Weight is a noisy signal — daily variation of one to two kilograms from glycogen, sodium and gut contents — so a fortnight of flat readings is well inside the noise band. Before concluding anything, look at a rolling weekly average over at least four weeks and at a tape measure, because recomposition shows up in circumference before it shows up in weight. Then track intake honestly for a week: appetite suppression fades unevenly, and intake creeping back up is the single commonest cause.

47 17jason_sac26, chris_chi24, tampaLisa73 and 44 others
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FranDenver
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Oct 2024
Denver, CO
May 30, 2024 at 3:55 PM#4
rick_sfbay said:
Thirteen weeks at the same dose with no change on the scale, and I have gone from assuming it was the drug to assuming it was me and back several…

Second this. Posting only so the count is not one.

46 16MASHdoc_SA, GenomicsKate, Dr.ObesityMed and 43 others
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Dr.BariatricHTX
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May 30, 2024 at 4:25 PM#5

From the other side of the consultation, briefly. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.

45 15maya_sedona, stefan_berlin, Dr.EM_Chicago and 42 others
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