🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsCOA & Analytical TestingHas anyone dealt with moisture content analysis for lyophilized peptides? Page 8

Has anyone dealt with moisture content analysis for lyophilized peptides?

newstart_MO Thu, May 30, 2024 at 8:42 AM 54 replies 2,788 viewsPage 8 of 11
Dr.NateNeph
VIP Member
2,987
16,234
Dec 2023
Houston, TX
Dec 23, 2024 at 5:14 PM#36

From the other side of the consultation, briefly. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

Last edited: Dec 23, 2024 at 7:14 PM
45 18JakeSmashed95, NauseaFreeNow, SteveThurs and 42 others
Reply Quote Save Share Report
PharmHunterJen
Member
567
2,345
Jul 2024
Illinois
Jan 4, 2025 at 9:41 AM#37
Dr.NateNeph said:
If two explanations both fit, the useful question is which one predicts something the other does not.

Mine went the same way, slower.

Last edited: Jan 4, 2025 at 3:41 PM
46 19alex_tucson, kevin_tulsa, Dr.PainCLE and 43 others
Reply Quote Save Share Report
BariatricNurseD
Senior Member
1,678
7,234
Feb 2024
Dallas, TX
Online
Jan 16, 2025 at 2:01 AM#38
Dr.NateNeph said:
If two explanations both fit, the useful question is which one predicts something the other does not.

Adding the part of the answer the thread has not reached. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

47 20josh_phd_bmore, roxy_nash, tony_orlando and 44 others
Reply Quote Save Share Report

Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards
Dr.PathRoch
Member
456
2,123
Jun 2024
Rochester, MN
Jan 27, 2025 at 6:14 PM#39

Adding the numbers, since they settle part of this. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

48 21SaraMom3, Dr.MetabolicMD, RetaRick_CA and 45 others
Reply Quote Save Share Report
tony_orlando
Member
234
1,123
Nov 2024
Orlando, FL
Feb 8, 2025 at 10:20 AM#40

One thing that is still open after Dr.NateNeph’s answer:

How would you tell the difference between that and the alternative explanation?

Last edited: Feb 8, 2025 at 11:20 AM
20 18KetoKyle, CanadaChris, ZaraB_AL and 17 others
Reply Quote Save Share Report

Similar Threads

HPLC vs UPLC for peptide purity — method comparison study18 replies
Mass spectrometry for peptide identity verification — ESI-MS guide7 replies
Endotoxin testing methods — LAL vs recombinant Factor C17 replies
Red flags on COAs — how to spot a fake certificate5 replies
USP reference standards for peptide verification — sourcing guide3 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register