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ForumsPharmacology & MechanismsTachyphylaxis vs tolerance — 12 month update Page 3

Tachyphylaxis vs tolerance — 12 month update

FranDenver Mon, Dec 15, 2025 at 10:13 PM 39 replies 1,780 viewsPage 3 of 8
Dr.MetabolicMD
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Dec 22, 2025 at 11:26 AM#11
GenomicsKate said:
Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…

True, and it depends on a baseline nobody has stated. Without knowing where someone started, the same number can be an excellent result or a disappointing one.

Last edited: Dec 22, 2025 at 1:26 PM
6 4SleepDoc_PDX, RegAffairsDC, BiostatsBrad and 3 others
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andrew_nyc
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Dec 24, 2025 at 3:54 AM#12
NauseaFreeNow said:
The pharmacokinetics explain nearly every practical question asked here.

Genuinely useful, thank you. I had the facts and not the framework. I will report back once I have actually tried it.

Last edited: Dec 24, 2025 at 8:54 AM
7 5Dr.NateNeph, PharmD_Rodriguez, julia.endo and 4 others
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DoseLogDan
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Dec 25, 2025 at 8:22 PM#13
GenomicsKate said:
Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

8 6mel_PDX, Dr.AddMedPHL, newstart_MO and 5 others
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NicoleRaleigh
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Dec 27, 2025 at 12:49 PM#14

Adding the numbers, since they settle part of this. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

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mike_mod
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Dec 29, 2025 at 5:15 AM#15

Moderator note: a couple of off-topic posts removed.

Last edited: Dec 29, 2025 at 7:15 AM
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