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ForumsPharmacology & MechanismsTachyphylaxis vs tolerance — 12 month update Page 4

Tachyphylaxis vs tolerance — 12 month update

FranDenver Mon, Dec 15, 2025 at 10:13 PM 39 replies 1,780 viewsPage 4 of 8
jim_asheville
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Dec 30, 2025 at 9:40 PM#16

Clinical perspective, offered as context rather than as advice. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

11 9MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 8 others
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anders_CPH
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Jan 1, 2026 at 2:04 PM#17

Adding the numbers, since they settle part of this. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

12 10MariaRD, AussieAnna, BethLabQueen and 9 others
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tyler_CSCS
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Jan 3, 2026 at 6:27 AM#18

Following on from NicoleRaleigh — and this may be the naive question:

What did you change at the same time, and can you separate the two now?

13 11Dr.SportsMedIN, amy_econ_NJ, bbq_ray_KC and 10 others
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Dr.PeteFamMed
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Jan 4, 2026 at 10:49 PM#19
anders_CPH said:
If you are going to change something, change one thing and give it long enough to express itself.

This is where I part company with the consensus forming above. The counter-case has not been addressed. Somebody upthread described the situation that does not fit, and the thread moved on rather than engaging with it, which is the failure mode this board is supposed to avoid.

14 12Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 11 others
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Admin
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Jan 6, 2026 at 3:10 PM#20

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Tagging this one for the weekly digest.

Last edited: Jan 6, 2026 at 7:10 PM
36 9PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 33 others
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