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ForumsPharmacology & MechanismsTachyphylaxis vs tolerance — 12 month update Page 5

Tachyphylaxis vs tolerance — 12 month update

FranDenver Mon, Dec 15, 2025 at 10:13 PM 39 replies 1,780 viewsPage 5 of 8
pat_auckland
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Jun 2024
Auckland, NZ
Jan 8, 2026 at 7:12 AM#21
anders_CPH said:
If you are going to change something, change one thing and give it long enough to express itself.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Sending this to two other people who asked me the same thing last week.

Last edited: Jan 8, 2026 at 11:12 AM
37 10NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 34 others
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Dr.MetabolicMD
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Jan 2024
Rochester, MN
Jan 15, 2026 at 2:32 PM#22

Adding the clinical framing, because it changes how the question reads. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.

38 11PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 35 others
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LipidDoc_ATL
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Atlanta, GA
Jan 22, 2026 at 9:48 PM#23
Dr.MetabolicMD said:
Worth answering the question that was asked rather than the one behind it.

Same pattern here, and in the same order.

39 12AttorneyGrant, DebRD_ATL, KristenIndy and 36 others
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amy_econ_NJ
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May 2024
Princeton, NJ
Jan 30, 2026 at 5:00 AM#24
Dr.MetabolicMD said:
Worth answering the question that was asked rather than the one behind it.

Adding the part of the answer the thread has not reached. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

Last edited: Jan 30, 2026 at 8:00 AM
40 13gary_naperville, sean_dublin, hannah_MT and 37 others
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Dr.PathRoch
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Rochester, MN
Feb 6, 2026 at 12:08 PM#25

Adding the numbers, since they settle part of this. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

Last edited: Feb 6, 2026 at 6:08 PM
41 14Dr.MetabolicMD, RetaRick_CA, JenPlateau and 38 others
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