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ForumsPharmacology & MechanismsTachyphylaxis vs tolerance — 12 month update Page 7

Tachyphylaxis vs tolerance — 12 month update

FranDenver Mon, Dec 15, 2025 at 10:13 PM 39 replies 1,780 viewsPage 7 of 8
Dr.EndoEP
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Mar 22, 2026 at 3:55 AM#31
FranDenver said:
Closing this out: the trough rather than the peak explains the pattern I was seeing on day six, which I had been blaming on the vial.

Mine went the same way, slower.

18 16NicoleRaleigh, james_edin, FranDenver and 15 others
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JenPlateau
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Mar 29, 2026 at 9:05 AM#32
FranDenver said:
Closing this out: the trough rather than the peak explains the pattern I was seeing on day six, which I had been blaming on the vial.

Adding the part of the answer the thread has not reached. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.

I would rather be corrected than agreed with, if it comes to it.

19 17TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 16 others
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dave_SLC
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Apr 5, 2026 at 2:10 PM#33

Adding the numbers, since they settle part of this. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

Happy to go further on any of that.

20 18james_edin, FranDenver, Dr.BariatricHTX and 17 others
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A1cHero_PHX
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Apr 12, 2026 at 7:12 PM#34

One thing that is still open after FranDenver’s answer:

How would you tell the difference between that and the alternative explanation?

21 19chris_chi24, tampaLisa73, KarenAZ_mom and 18 others
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KevinCompounds
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Apr 20, 2026 at 12:09 AM#35
dave_SLC said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.

22 20NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 19 others
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