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ForumsPharmacology & MechanismsTachyphylaxis vs tolerance — 12 month update Page 6

Tachyphylaxis vs tolerance — 12 month update

FranDenver Mon, Dec 15, 2025 at 10:13 PM 39 replies 1,780 viewsPage 6 of 8
labquiet_amy
Senior Member
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Mar 2024
Cambridge, MA
Feb 13, 2026 at 7:11 PM#26

One thing that is still open after Dr.MetabolicMD’s answer:

How long did you give it before you decided it was working?

42 15TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 39 others
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hannah_MT
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Feb 2026
Bozeman, MT
Feb 21, 2026 at 2:10 AM#27
Dr.PathRoch said:
Worth stating the units and the reference range whenever you post a number here.

I read this differently from Dr.PathRoch, on substance rather than tone. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

43 16MounjBrad, nick_newbie, DadBodDave and 40 others
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claudia_zurich
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Zurich, CH
Feb 28, 2026 at 9:05 AM#28
Dr.PathRoch said:
Worth stating the units and the reference range whenever you post a number here.

That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.

Last edited: Feb 28, 2026 at 3:05 PM
44 17Dr.LipidDallas, alex_tucson, kevin_tulsa and 41 others
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KarenAZ_mom
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Scottsdale, AZ
Mar 7, 2026 at 3:55 PM#29
Dr.PathRoch said:
Worth stating the units and the reference range whenever you post a number here.

Thank you for spelling out the reasoning rather than just the conclusion.

Last edited: Mar 7, 2026 at 8:55 PM
45 18LibrarianMeg, bri_stats, pete_manc_UK and 42 others
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FranDenver
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Oct 2024
Denver, CO
Mar 14, 2026 at 10:42 PM#30

Reporting back.

Closing this out: the trough rather than the peak explains the pattern I was seeing on day six, which I had been blaming on the vial.

17 15GenomicsKate, Dr.ObesityMed, HealthEcon_DC and 14 others
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