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ForumsPharmacology & MechanismsHas anyone dealt with molecular dynamics simulations of glp-1r binding? Page 5

Has anyone dealt with molecular dynamics simulations of glp-1r binding?

BrianDallas92 Wed, Apr 16, 2025 at 2:37 AM 36 replies 1,942 viewsPage 5 of 8
TirzTom
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May 16, 2025 at 11:20 PM#21

One concrete data point for the thread. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

21 19josh_phd_bmore, roxy_nash, tony_orlando and 18 others
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tommy_boulder
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May 29, 2025 at 9:43 AM#22

One thing that is still open after anna.melb_AU’s answer:

How would you tell the difference between that and the alternative explanation?

22 20TinaHashiRN, robert_kc, dan_philly and 19 others
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ingrid_STO
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Jun 10, 2025 at 7:59 PM#23
TirzTom said:
Say what you would expect to see if you were wrong, before you look.

I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.

23 21MikeFit_NJ, InsuranceTom, WendyG_ATL and 20 others
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DoseLogDan
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Jun 23, 2025 at 6:07 AM#24
TirzTom said:
Say what you would expect to see if you were wrong, before you look.

Agreed, with the usual condition: that holds for the average and this board is a collection of individuals. A population claim and a personal prediction are different things and get quoted interchangeably.

24 22sophie_paris, mel_PDX, Dr.AddMedPHL and 21 others
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MarkLI_maint
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Jul 5, 2025 at 4:08 PM#25
TirzTom said:
Say what you would expect to see if you were wrong, before you look.

Thank you for spelling out the reasoning rather than just the conclusion. I will report back once I have actually tried it.

25 23bri_stats, pete_manc_UK, anna.melb_AU and 22 others
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