🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsBiased agonism at GLP-1R — 12 month update Page 10

Biased agonism at GLP-1R — 12 month update

pam_columbus Tue, Dec 17, 2024 at 6:06 AM 52 replies 2,746 viewsPage 10 of 11
SallyK_inj
Member
567
2,345
Jul 2024
Iowa
Dec 19, 2025 at 11:06 AM#46
Dr.AddMedPHL said:
It helps to say which part of this you are uncertain about.

Second this.

49 22amy_econ_NJ, bbq_ray_KC, oliver_london and 46 others
Reply Quote Save Share Report
pam_columbus
Member
312
1,345
Aug 2024
Columbus, OH
Jan 1, 2026 at 1:31 PM#47

Closing the loop on my own question.

Late follow-up. I did not do what was suggested, I did something adjacent, and it worked; posting the difference in case it matters to somebody.

50 23alex_tucson, kevin_tulsa, Dr.PainCLE and 47 others
Reply Quote Save Share Report
LabKate
Senior Member
2,678
11,234
Jan 2024
Oregon
Jan 14, 2026 at 3:48 PM#48

The figures, for anyone assembling their own picture. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

1 24Dr.SleepRoch
Reply Quote Save Share Report

Janoshik Analytical — Independent Testing

Trusted third-party HPLC & mass spectrometry analysis. Verify peptide purity with the lab the community relies on. Independent. Accurate. Transparent.

Verify Your Peptides

GL Biochem (Shanghai) Ltd. — Direct Manufacturer

Est. 1998. The synthesis house behind the vials you send for testing. ISO 9001 and cGMP certified, 1,500+ staff, batch-specific COA with every order.

Browse GL Biochem
paige_pharma
Member
289
1,234
Sep 2024
Omaha, NE
Jan 27, 2026 at 5:57 PM#49

One thing that is still open after Dr.AddMedPHL’s answer:

Was that from a primary source or from a summary of one?

Last edited: Jan 27, 2026 at 6:57 PM
2 0lisa_labSD, adam_van
Reply Quote Save Share Report
FitDadDave
Member
534
2,678
Jul 2024
Minneapolis, MN
Feb 9, 2026 at 7:59 PM#50
LabKate said:
For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

This is where I part company with the consensus forming above. The counter-case has not been addressed. Somebody upthread described the situation that does not fit, and the thread moved on rather than engaging with it, which is the failure mode this board is supposed to avoid.

24 22jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 21 others
Reply Quote Save Share Report

Similar Threads

GLP-1R desensitization — β-arrestin-mediated internalization18 replies
Biased agonism at GLP-1R — Gs vs β-arrestin signaling balance13 replies
Semaglutide albumin binding and the C-18 fatty acid linker17 replies
GIP receptor pharmacology — why GIP agonism enhances GLP-113 replies
Glucagon receptor signaling — hepatic glycogenolysis and lipolysis16 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register