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ForumsPharmacology & MechanismsBiased agonism at GLP-1R — 12 month update Page 11

Biased agonism at GLP-1R — 12 month update

pam_columbus Tue, Dec 17, 2024 at 6:06 AM 52 replies 2,746 viewsPage 11 of 11
JenPlateau
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Feb 22, 2026 at 7:15 PM#51
LabKate said:
For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

Agreed, with the usual condition: that holds for the average and this board is a collection of individuals. A population claim and a personal prediction are different things and get quoted interchangeably.

25 23HPLC_Greg, LibrarianMeg, bri_stats and 22 others
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KristenIndy
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Mar 7, 2026 at 6:23 PM#52

Old thread, but it comes up first when you search for this, so it is worth updating. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.

26 24amsterdam_pete, LondonLisa, mike_nyc and 23 others
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jim_asheville
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Mar 20, 2026 at 5:24 PM#53

Adding the clinical framing, because it changes how the question reads. Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third retelling.

Last edited: Mar 20, 2026 at 8:24 PM
27 0NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 24 others
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Dr.CardioMD
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Apr 2, 2026 at 4:17 PM#54
jim_asheville said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

This is my experience too, for whatever a second data point is worth. I had assumed I was the exception until I read this.

28 1roxy_nash, tony_orlando, Dr.NephBHM_UK and 25 others
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mike.trainer_LA
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Apr 15, 2026 at 3:03 PM#55
jim_asheville said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

There is a second half to this that has not been said yet. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

Last edited: Apr 15, 2026 at 7:03 PM
29 2marcus_mpls, DeniseRN_TPA, SandraNC_45 and 26 others
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