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ForumsPharmacology & MechanismsBiased agonism at GLP-1R — 12 month update Page 9

Biased agonism at GLP-1R — 12 month update

pam_columbus Tue, Dec 17, 2024 at 6:06 AM 52 replies 2,746 viewsPage 9 of 11
Dr.RenalNash
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Oct 14, 2025 at 9:09 PM#41

One thing that is still open after Dr.AddMedPHL’s answer:

What would you measure differently if you were starting again?

44 17wei_SG, cory_ATX, lori_vegas and 41 others
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tammy_FL
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Oct 28, 2025 at 12:12 AM#42
TirzTom said:
One habit that pays for itself: post the method alongside the number.

Pushing back on TirzTom here. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

Last edited: Oct 28, 2025 at 6:12 AM
45 18alex_tucson, kevin_tulsa, Dr.PainCLE and 42 others
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mike_mod
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Nov 10, 2025 at 3:07 AM#43

Moderator note: a couple of off-topic posts removed. Thread quality here is what the rules are for. Keep it up.

46 19DoseLogDan, SleepFixSam, PurityPaulOR and 43 others
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SleepDoc_PDX
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Nov 23, 2025 at 5:54 AM#44
TirzTom said:
One habit that pays for itself: post the method alongside the number.

Saving this. It is the first explanation that did not require me to already understand it. Printing the relevant bit and taking it with me.

Last edited: Nov 23, 2025 at 8:54 AM
47 20sophie_paris, mel_PDX, Dr.AddMedPHL and 44 others
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Dr.AddMedPHL
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Dec 6, 2025 at 8:34 AM#45

From the other side of the consultation, briefly. It helps to say which part of this you are uncertain about. A precise question gets a precise answer; a general one gets everybody’s favourite anecdote.

Last edited: Dec 6, 2025 at 10:34 AM
48 21JessicaM_2024, TomFromTexas, mike.trainer_LA and 45 others
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