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ForumsPharmacology & MechanismsBiased agonism at GLP-1R — 12 month update Page 4

Biased agonism at GLP-1R — 12 month update

pam_columbus Tue, Dec 17, 2024 at 6:06 AM 52 replies 2,746 viewsPage 4 of 11
Dr.ReproEndo
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Jan 6, 2025 at 12:07 PM#16

Clinical perspective, offered as context rather than as advice. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

Last edited: Jan 6, 2025 at 1:07 PM
6 4mona_PHX, andrew_nyc, Dr.EndoEP and 3 others
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rick_sfbay
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Jan 9, 2025 at 10:17 AM#17

A narrower follow-up, since the general answer is now clear:

How long did you give it before you decided it was working?

7 5NicoleRaleigh, james_edin, FranDenver and 4 others
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VendorMark
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Jan 12, 2025 at 8:25 AM#18
Dr.ReproEndo said:
It is worth asking what the claim would look like if it were false.

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

8 6MarkLI_maint, Dr.PeteFamMed, claudia_zurich and 5 others
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anna.melb_AU
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Jan 15, 2025 at 6:32 AM#19
Dr.ReproEndo said:
It is worth asking what the claim would look like if it were false.

Right, and the exception is worth naming rather than left implied, because the exception is where people get into trouble.

9 7tammy_FL, Dr.LipidDallas, alex_tucson and 6 others
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Admin
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Jan 18, 2025 at 4:37 AM#20

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Report rather than reply if it drifts again.

Last edited: Jan 18, 2025 at 8:37 AM
31 4PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 28 others
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