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ForumsPharmacology & MechanismsBiased agonism at GLP-1R — 12 month update Page 5

Biased agonism at GLP-1R — 12 month update

pam_columbus Tue, Dec 17, 2024 at 6:06 AM 52 replies 2,746 viewsPage 5 of 11
Dr.EM_Chicago
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Jan 21, 2025 at 2:09 AM#21

From the other side of the consultation, briefly. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.

Last edited: Jan 21, 2025 at 6:09 AM
32 5jim_asheville, matt_MKE, Dr.ReproEndo and 29 others
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Dr.DermMIA
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Feb 3, 2025 at 1:09 PM#22
Dr.EM_Chicago said:
The version of this that has an answer is narrower than the version being asked.

Same pattern here, and in the same order.

33 6Dr.RenalNash, LipidDoc_ATL, BariatricNurseD and 30 others
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quinn_sf
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Feb 17, 2025 at 12:01 AM#23
Dr.EM_Chicago said:
The version of this that has an answer is narrower than the version being asked.

Coming at Dr.EM_Chicago’s question from a different direction. Start from the measurement rather than the conclusion. Almost every disagreement here turns out to be two people measuring different things and comparing the numbers anyway.

Last edited: Feb 17, 2025 at 6:01 AM
34 7mona_PHX, andrew_nyc, Dr.EndoEP and 31 others
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DanielChem_CHI
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Mar 2, 2025 at 10:46 AM#24

The figures, for anyone assembling their own picture. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

35 8ben_calgary, patPC_UT, Dr.DermMIA and 32 others
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KarenAZ_mom
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Mar 15, 2025 at 9:23 PM#25

Following on from Dr.EM_Chicago — and this may be the naive question:

How would you tell the difference between that and the alternative explanation?

36 9HPLC_Greg, LibrarianMeg, bri_stats and 33 others
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