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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsIs oral sema actually as effective as the injection version? — 12 month update Page 3

Is oral sema actually as effective as the injection version? — 12 month update

tommy_boulder Tue, Dec 16, 2025 at 3:17 AM 35 replies 1,548 viewsPage 3 of 7
anders_CPH
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Dec 17, 2025 at 2:24 PM#11
carl_compliance said:
If two explanations both fit, the useful question is which one predicts something the other does not.

True, and it depends on a baseline nobody has stated. Without knowing where someone started, the same number can be an excellent result or a disappointing one.

Happy to go further on any of that.

14 14CryptoCarl, MariaRD, AussieAnna and 11 others
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pete_nash
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Dec 18, 2025 at 7:37 AM#12
CanadaChris said:
Worth adding that the tablet is taken daily, so a missed dose costs far less than a missed weekly injection.

This answered a question I did not know how to ask. I will report back once I have actually tried it.

13 13Dr.Martinez, mike_mod, SarahChen_PharmD and 10 others
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quinn_sf
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Dec 19, 2025 at 12:51 AM#13
carl_compliance said:
If two explanations both fit, the useful question is which one predicts something the other does not.

I read this differently from carl_compliance, on substance rather than tone. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

Last edited: Dec 19, 2025 at 6:51 AM
12 12mona_PHX, andrew_nyc, Dr.EndoEP and 9 others
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DanielChem_CHI
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Dec 19, 2025 at 6:05 PM#14

One concrete data point for the thread. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

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mike_mod
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Dec 20, 2025 at 11:19 AM#15

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Report rather than reply if it drifts again.

Last edited: Dec 20, 2025 at 1:19 PM
10 10PurityPaulOR, MaxMetOK, MounjBrad and 7 others
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