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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOff-TopicNew Year goals check-in — looking for input Page 3

New Year goals check-in — looking for input

julia.endo Tue, Dec 17, 2024 at 3:40 PM 33 replies 1,847 viewsPage 3 of 7
CarlaRPh_TPA
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Dec 18, 2024 at 9:46 AM#11
PharmHunterJen said:
Alcohol relationship change with food noise: I used to drink 3-4 beers most nights.
PharmHunterJen said:
...regarding food noise mechanism of action...

To build on this — the mechanism is more complex than "it makes you less hungry." GLP-1 agonists:

  1. Activate hypothalamic satiety centers (appetite reduction)
  2. Delay gastric emptying (prolonged fullness)
  3. Potentiate glucose-dependent insulin secretion
  4. Suppress glucagon secretion
  5. Modulate reward pathway dopaminergic signaling
  6. Reduce hepatic lipogenesis
  7. Have direct cardiovascular protective effects

It's a multi-target drug with systemic metabolic effects. Understanding the mechanism helps us predict and manage side effects.

9 9FDA_TrackerJim, ricardo_MIA, BrianDallas92 and 6 others
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rachel_ABQ
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Albuquerque, NM
Dec 18, 2024 at 3:49 PM#12
nick_SD_fit said:
Rebound hunger after missed dose of food noise: I missed my injection by 3 days due to a shipping delay and the hunger came ROARING back.

That reframing is the part I needed. Sending this to two other people who asked me the same thing last week.

8 8DadBodDave, AmyNC_wife, SkepticalSean and 5 others
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AussieAnna
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Sydney, AU
Dec 18, 2024 at 9:52 PM#13
PharmHunterJen said:
Alcohol relationship change with food noise: I used to drink 3-4 beers most nights.

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

7 7LibrarianMeg, bri_stats, pete_manc_UK and 4 others
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BiostatsBrad
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Dec 19, 2024 at 3:56 AM#14

Adding the numbers, since they settle part of this. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

Last edited: Dec 19, 2024 at 4:56 AM
6 6james_edin, FranDenver, Dr.BariatricHTX and 3 others
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mike_mod
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Dec 19, 2024 at 10:00 AM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Report rather than reply if it drifts again.

5 5PurityPaulOR, MaxMetOK, MounjBrad and 2 others
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