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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOff-TopicDate night restaurant recommendations — 12 month update Page 3

Date night restaurant recommendations — 12 month update

ChrisMacros Tue, Jan 9, 2024 at 12:19 PM 11 replies 2,104 viewsPage 3 of 3
Dr.KarenChen
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Jan 11, 2024 at 5:44 AM#11
Dr.SurgeonPGH said:
The GLP-1 and alcohol use disorder connection, relevant to food noise: observational data from Scandinavian registries shows reduced alcohol-related…
Dr.SurgeonPGH said:
...regarding food noise mechanism of action...

To build on this — the mechanism is more complex than "it makes you less hungry." GLP-1 agonists:

  1. Activate hypothalamic satiety centers (appetite reduction)
  2. Delay gastric emptying (prolonged fullness)
  3. Potentiate glucose-dependent insulin secretion
  4. Suppress glucagon secretion
  5. Modulate reward pathway dopaminergic signaling
  6. Reduce hepatic lipogenesis
  7. Have direct cardiovascular protective effects

It's a multi-target drug with systemic metabolic effects. Understanding the mechanism helps us predict and manage side effects.

44 17julia.endo, JessicaM_2024, TomFromTexas and 41 others
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hannah_MT
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Bozeman, MT
Jan 12, 2024 at 8:28 AM#12
MounjBrad said:
Phantom hunger vs real hunger on food noise: learning to distinguish between the two has been a revelation.

Genuinely useful, thank you. I had the facts and not the framework. Printing the relevant bit and taking it with me.

45 18MounjBrad, nick_newbie, DadBodDave and 42 others
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AmyNC_wife
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Jan 13, 2024 at 11:13 AM#13
Dr.SurgeonPGH said:
The GLP-1 and alcohol use disorder connection, relevant to food noise: observational data from Scandinavian registries shows reduced alcohol-related…

Pushing back on Dr.SurgeonPGH here. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

Last edited: Jan 13, 2024 at 12:13 PM
46 19PharmD_Rodriguez, julia.endo, JessicaM_2024 and 43 others
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BiostatsBrad
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Jan 14, 2024 at 1:59 PM#14

Adding the numbers, since they settle part of this. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

47 20james_edin, FranDenver, Dr.BariatricHTX and 44 others
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Admin
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Jan 15, 2024 at 4:45 PM#15

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Carry on.

Last edited: Jan 15, 2024 at 8:45 PM
48 21PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 45 others
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