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ForumsOral GLP-1 AgonistsOrforglipron Phase 3 ATTAIN-1 topline — anyone have experience? Page 3

Orforglipron Phase 3 ATTAIN-1 topline — anyone have experience?

steve_okc Sat, Apr 26, 2025 at 11:16 AM 30 replies 1,800 viewsPage 3 of 6
Dr.GastroMayo
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Apr 28, 2025 at 7:13 PM#11
Dr.ObesityLA said:
Relative and absolute effects need reading together.

Agreed, with the usual condition: that holds for the average and this board is a collection of individuals. A population claim and a personal prediction are different things and get quoted interchangeably.

50 23mike_nyc, VendorMark, COA_Karl and 47 others
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LeilaHI
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Apr 29, 2025 at 6:33 AM#12
Dr.EM_Chicago said:
Orforglipron is a small molecule rather than a peptide, which is the whole point: no SNAC absorption enhancer, no fasting window, no cold chain, and…

This is exactly what I could not find anywhere else. Printing the relevant bit and taking it with me.

Last edited: Apr 29, 2025 at 11:33 AM
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GenomicsKate
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Apr 29, 2025 at 5:54 PM#13
Dr.ObesityLA said:
Relative and absolute effects need reading together.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I would add the less popular caveat: these trial populations under-represented several groups, older adults and the highest BMI categories among them. The results probably generalise, and "probably" should be stated as an assumption rather than dropped.

Correct me if the detail matters more than I have assumed.

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HPLC_Greg
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Apr 30, 2025 at 5:15 AM#14

The figures, for anyone assembling their own picture. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

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Admin
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Apr 30, 2025 at 4:36 PM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Tagging this one for the weekly digest.

4 2PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 1 other
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