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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCardiovascular OutcomesSELECT cost-effectiveness — looking for input Page 8

SELECT cost-effectiveness — looking for input

claudia_zurich Tue, Nov 11, 2025 at 1:22 PM 36 replies 1,506 viewsPage 8 of 8
JessicaM_2024
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Dec 27, 2025 at 8:49 AM#36
SleepDoc_PDX said:
I want to bring up the cardiovascular angle on cardiovascular risk.

Bookmarking. The distinction being drawn above is the one nobody else makes. I will report back once I have actually tried it.

8 8james_edin, FranDenver, Dr.BariatricHTX and 5 others
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traveltech_sara
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Dec 29, 2025 at 3:04 PM#37

Clinical perspective, offered as context rather than as advice.

Positive "side effect" of cardiovascular risk: my blood pressure dropped so much that I'm now off losartan entirely! My cardiologist is thrilled.

If you're on BP meds and losing weight on a GLP-1, monitor your BP at home regularly. Hypotension symptoms (dizziness, lightheadedness when standing) mean your BP meds may need reduction. Don't wait for your next scheduled appointment — call your doctor.

7 7LarryQC_SD, wanda_boise, NurseAsh_DET and 4 others
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Dr.ObesityMed
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Dec 31, 2025 at 9:20 PM#38
traveltech_sara said:
Positive "side effect" of cardiovascular risk: my blood pressure dropped so much that I'm now off losartan entirely!

This is my experience too, for whatever a second data point is worth.

6 6SurmountFan_IN, PeptideChemSF, A1cHero_PHX and 3 others
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sean_dublin
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Jan 3, 2026 at 3:38 AM#39
traveltech_sara said:
Positive "side effect" of cardiovascular risk: my blood pressure dropped so much that I'm now off losartan entirely!

I'm 58 years old and want to share my perspective on cardiovascular risk as an older member of this community.

My doctor was initially hesitant because of my age, but the SELECT trial included patients up to 72 and showed consistent benefit across age groups. We started at the lowest dose with closer monitoring.

16 months later: down 53 lbs, off lisinopril, A1C from 8.6% to 5.4%. My cardiologist is thrilled. cardiovascular risk is absolutely relevant for older adults — don't let anyone tell you otherwise.

Last edited: Jan 3, 2026 at 4:38 AM
5 5NurseLeah_Nash, gary_naperville, sean_dublin and 2 others
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kate.chem
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Jan 5, 2026 at 9:57 AM#40

One concrete data point for the thread. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

Happy to go further on any of that.

33 8Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 30 others
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