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Evidence-based GLP-1 & peptide discussion since 2023
ForumsLab Results & BiomarkersCholesterol dropped 80 points and my doc is shook Page 2

Cholesterol dropped 80 points and my doc is shook

dan_philly Sat, May 9, 2026 at 10:28 AM 23 replies 941 viewsPage 2 of 5
Dr.SleepRoch
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Rochester, MN
May 10, 2026 at 9:43 AM#6
amsterdam_pete said:
Advanced lipoprotein testing on the lipid panel — going beyond standard lipid panel: Marker Baseline Month 8 Clinical Meaning LDL-P 1668 968 Particle…

Careful with treating an unchanged LDL-C as a failure. If ApoB and triglycerides both fell, the particle picture improved regardless of what the calculated LDL says.

Happy to go further on any of that.

36 14sarah_TO, wendy_avl, jason_paloalto and 33 others
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kate.chem
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May 10, 2026 at 6:57 PM#7
dan_philly said:
Trying to work out whether my panel improved or merely rearranged itself, because two of the numbers went the wrong way.

Before/after bloodwork compilation for the lipid panel — everything in one place for those who want comprehensive data:

CategoryMarkerBeforeAfter 13moChange
MetabolicA1C7.2%5.5%⬇️ 1.4%
MetabolicFasting Glucose12190⬇️ 26
LipidsLDL14993⬇️ 41
LipidsTriglycerides221111⬇️ 111
InflammationhsCRP6.50.9⬇️ 5.0

Every single metabolic marker improved. This is why I'm a believer in this therapy.

Last edited: May 10, 2026 at 9:57 PM
37 15VanRx_Mike, steve_okc, dave_SLC and 34 others
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Dr.CardioMD
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Cleveland, OH
May 11, 2026 at 4:11 AM#8
Dr.SleepRoch said:
Careful with treating an unchanged LDL-C as a failure.

Omega-3 index improvement on the lipid panel: often overlooked but my omega-3 index went from 3.8% to 7.8% over 11 months. I supplemented with 2g EPA+DHA daily.

This matters because omega-3s are anti-inflammatory and cardioprotective, complementing the GLP-1 benefits. Target omega-3 index is >8%. Combined with the triglyceride reduction from the medication, my lipid profile is the best it's been in decades.

38 16tony_orlando, Dr.NephBHM_UK, kim_atl_prep and 35 others
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RunnerRach
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Aug 2024
Boston, MA
May 11, 2026 at 1:25 PM#9

One thing that is still open after wanda_boise’s answer:

What did you change at the same time, and can you separate the two now?

39 17jennifer_SEA, tyler_CSCS, VanRx_Mike and 36 others
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dan_philly
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Jul 2024
Philadelphia, PA
May 13, 2026 at 9:43 AM#10

Closing the loop on my own question.

For the archive: it took about six weeks rather than the two I expected, and the difference between those two numbers was the whole of my problem.

Last edited: May 13, 2026 at 12:43 PM
3 3EndoResFellow, PharmacoVig_BOS, SurmountFan_IN
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