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Evidence-based GLP-1 & peptide discussion since 2023
ForumsLab Results & BiomarkersCholesterol dropped 80 points and my doc is shook

Cholesterol dropped 80 points and my doc is shook

dan_philly Sat, May 9, 2026 at 10:28 AM 23 replies 941 viewsPage 1 of 5
dan_philly
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Jul 2024
Philadelphia, PA
May 9, 2026 at 10:28 AM#1

Trying to work out whether my panel improved or merely rearranged itself, because two of the numbers went the wrong way.

What I actually want to know is whether an unchanged LDL-C alongside a large triglyceride fall is a good result or a bad one, because ApoB and LDL-C seem to be telling different stories.

I would rather have one careful answer than five confident ones.

31 9DadBodDave, AmyNC_wife, SkepticalSean and 28 others
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amsterdam_pete
Senior Member
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Feb 2024
Netherlands
May 9, 2026 at 12:03 PM#2
dan_philly said:
Trying to work out whether my panel improved or merely rearranged itself, because two of the numbers went the wrong way.

Advanced lipoprotein testing on the lipid panel — going beyond standard lipid panel:

MarkerBaselineMonth 8Clinical Meaning
LDL-P1668968Particle count (more precise than LDL-C)
Small dense LDL68%32%Atherogenic pattern
Remnant cholesterol3617Triglyceride-rich lipoproteins
oxLDL7346Oxidative stress marker

The shift from small dense to large buoyant LDL is particularly important — it represents a fundamental change in the atherogenic profile.

Last edited: May 9, 2026 at 6:03 PM
32 10ZaraB_AL, JakeSmashed95, NauseaFreeNow and 29 others
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wanda_boise
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Aug 2024
Boise, ID
May 9, 2026 at 1:38 PM#3
amsterdam_pete said:
Advanced lipoprotein testing on the lipid panel — going beyond standard lipid panel: Marker Baseline Month 8 Clinical Meaning LDL-P 1668 968 Particle…

Comprehensive lipid panel update relevant to the lipid panel:

MarkerBaseline6 Months12 MonthsReference
Total Cholesterol234199179<200
LDL14913499<100
HDL424956>40
Triglycerides21418999<150
LDL-P16941144944<1000

The triglyceride drop is the most impressive. My cardiologist reduced my statin dose based on these results.

33 11pam_columbus, nick_SD_fit, ben_calgary and 30 others
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SallyK_inj
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Jul 2024
Iowa
May 9, 2026 at 3:13 PM#4
dan_philly said:
Trying to work out whether my panel improved or merely rearranged itself, because two of the numbers went the wrong way.

Mine went the same way, slower.

34 12tane_welly, Dr.PathRoch, mona_PHX and 31 others
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sean_dublin
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Nov 2024
Dublin, IE
May 10, 2026 at 12:28 AM#5

Clinical perspective, offered as context rather than as advice.

Tracking labs for the lipid panel — here's the panel I get every 3 months and why:

  • CMP: glucose, electrolytes, kidney function, liver enzymes
  • Lipid panel: total cholesterol, LDL, HDL, triglycerides
  • A1C: 3-month glucose average
  • hsCRP: inflammatory marker
  • CBC: blood counts, anemia screening
  • B12, folate, iron: nutritional deficiency screening
  • TSH, free T4: thyroid monitoring
  • Lipase: pancreatic safety check

Total cost with insurance: about $32 copay. Without insurance, request cash-pay pricing from Quest/Labcorp — usually $187.

Last edited: May 10, 2026 at 1:28 AM
35 13quinn_sf, NurseLeah_Nash, gary_naperville and 32 others
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