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Evidence-based GLP-1 & peptide discussion since 2023
ForumsLab Results & BiomarkersUric acid trends on GLP-1 — anyone have experience?

Uric acid trends on GLP-1 — anyone have experience?

claudia_zurich Wed, Feb 18, 2026 at 3:02 PM 17 replies 1,125 viewsPage 1 of 4
claudia_zurich
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Feb 18, 2026 at 3:02 PM#1

Putting this up for argument rather than for agreement. I have read it twice and I am still not certain what it supports.

The single most useful discipline is bringing the whole panel to a clinician rather than one flagged value. One out-of-range result in isolation generates anxiety and unnecessary tests; the same result next to the trend and the rest of the panel usually generates a shrug.

Where I think it is weakest: the completion rate deserves as much attention as the headline, because a large effect among those who finished is a different claim from a large effect among those enrolled.

What I actually want to know is what actually belongs on a baseline panel, as opposed to the enormous list that gets pasted around here. Happy to be told the question itself is wrong.

Note on sourcing:
Figures above are from the primary publication rather than the press summary. If a number here disagrees with one you have, post yours and we will work out which of us is reading a secondary source.
21 16emma_london, tammy_FL, Dr.LipidDallas and 18 others
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Dr.RenalNash
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Feb 18, 2026 at 3:35 PM#2
claudia_zurich said:
The single most useful discipline is bringing the whole panel to a clinician rather than one flagged value.

Agreeing with claudia_zurich, and the qualification matters more than the agreement. Quarterly for the first year is convention rather than evidence, and it is defensible for a simple reason: it is roughly the interval over which HbA1c becomes informative again, since it reflects about three months of glycaemia. After the first year, and once doses are stable, annual is reasonable unless something specific is being followed.

Last edited: Feb 18, 2026 at 8:35 PM
20 15pam_stl, wei_SG, cory_ATX and 17 others
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PurityPaulOR
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Feb 18, 2026 at 4:08 PM#3
claudia_zurich said:
The single most useful discipline is bringing the whole panel to a clinician rather than one flagged value.

Pushing back on claudia_zurich here. I would drop the "get everything" instinct further than this thread does. Every extra test is another chance at a false positive, and incidental findings have their own cost in scans, biopsies and worry.

19 14Admin, Dr.Martinez, mike_mod and 16 others
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Dr.RheumBOS
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Feb 18, 2026 at 4:41 PM#4

Taking the question as asked, rather than the general version of it. A defensible baseline is short: HbA1c and fasting glucose, a lipid panel with ApoB if you can get it, ALT and AST, creatinine with eGFR, TSH, ferritin and B12, and a full blood count. That set catches the things that change, the things that explain symptoms, and the things that alter the prescribing decision. Almost everything else on the long circulating lists is either invariant, uninterpretable without a specific question, or an incidental finding waiting to cause an unnecessary workup.

18 13lori_vegas, Dr.PulmRoch, maya_sedona and 15 others
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mia_MS2
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Feb 18, 2026 at 7:42 PM#5
Dr.RenalNash said:
Quarterly for the first year is convention rather than evidence, and it is defensible for a simple reason: it is roughly the interval over which HbA1c…

Same experience, arrived at from the opposite direction. Posting only so the count is not one.

17 12VanRx_Mike, steve_okc, dave_SLC and 14 others
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