From the other side of the consultation, briefly. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.
Dr.ReproEndo said:The mechanism and the magnitude are separate questions.
Agreed, and the practical implication is not to over-read a single eGFR during a period of rapid loss and altered hydration. Trend, with UACR beside it.
Dr.ReproEndo said:The mechanism and the magnitude are separate questions.
Coming at Dr.ReproEndo’s question from a different direction. Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak. People who dose late are not losing a peak, they are letting the trough fall, and the appetite effect tracks the trough.
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Shop Reference StandardsAdding the numbers, since they settle part of this. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.