Adding the clinical framing, because it changes how the question reads. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.

PeptideChemSF said:

It helps to ask what evidence would change your mind before you look at any.

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

PeptideChemSF said:

It helps to ask what evidence would change your mind before you look at any.

Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.

PeptideChemSF said:

It helps to ask what evidence would change your mind before you look at any.

This answered a question I did not know how to ask.

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful.