From the other side of the consultation, briefly. Take it one variable at a time. Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent argument can untangle them after the fact.
anders_CPH said:If you are going to change something, change one thing and give it long enough to express itself.
This answered a question I did not know how to ask. Sending this to two other people who asked me the same thing last week.
Clinical perspective, offered as context rather than as advice. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.
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View Resultsjim_asheville said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
This matches mine closely enough to be worth saying so. The dose-response is real but shallow at the top. Across STEP 1 and STEP 4 the gap between 1.7mg and 2.4mg is a couple of percentage points of body weight on average, and the average is carrying a wide spread — plenty of people at 1.7mg sit above the 2.4mg mean. If a dose is working and tolerable, "working" is the relevant variable, not "maximal".
I would rather be corrected than agreed with, if it comes to it.