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ForumsSemaglutide (Ozempic / Wegovy)Semaglutide and joint pain improvement — looking for input Page 8

Semaglutide and joint pain improvement — looking for input

wanda_boise Sat, Aug 16, 2025 at 4:16 PM 44 replies 1,898 viewsPage 8 of 9
Dr.PathRoch
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Aug 29, 2025 at 5:16 PM#36
carl_compliance said:
It helps to ask what evidence would change your mind before you look at any.

There is a second half to this that has not been said yet. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

Last edited: Aug 29, 2025 at 11:16 PM
3 1MikeFit_NJ, InsuranceTom, WendyG_ATL
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BethLabQueen
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Aug 30, 2025 at 4:48 AM#37

Adding the numbers, since they settle part of this. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

4 2Dr.PulmRoch, maya_sedona, stefan_berlin and 1 other
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AttorneyGrant
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Aug 30, 2025 at 4:20 PM#38

A narrower follow-up, since the general answer is now clear:

How much of the between-person variation is pharmacokinetic and how much is just adherence measured badly?

5 3JenMemphis, pat_auckland, Dr.GastroMayo and 2 others
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SarahChen_PharmD
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Aug 31, 2025 at 3:51 AM#39
BethLabQueen said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

This is where I part company with the consensus forming above. I would resist the confidence. Half of what this board was certain about two years ago has since been quietly dropped, and nobody went back to correct the threads.

6 4TinaHashiRN, robert_kc, dan_philly and 3 others
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RetaRick_CA
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Aug 31, 2025 at 3:22 PM#40
BethLabQueen said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

No disagreement, though it depends on where somebody is starting from, and this thread has been assuming a starting point nobody stated.

Last edited: Aug 31, 2025 at 4:22 PM
28 1MounjBrad, nick_newbie, DadBodDave and 25 others
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