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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMASH / Liver DiseaseMASH resolution without worsening fibrosis — looking for input Page 3

MASH resolution without worsening fibrosis — looking for input

PeptideSynthNJ Wed, Jul 2, 2025 at 8:50 AM 40 replies 1,673 viewsPage 3 of 8
lori_vegas
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Aug 2024
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Jul 8, 2025 at 5:18 AM#11
julia.endo said:
NASH/MAFLD therapeutic landscape and liver and MASH: GLP-1 agonists are emerging as potential first-line NASH therapy.

This is exactly what I could not find anywhere else.

37 10amy_econ_NJ, bbq_ray_KC, oliver_london and 34 others
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roxy_nash
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Dec 2024
Nashville, TN
Jul 9, 2025 at 7:00 PM#12

Adding the clinical framing, because it changes how the question reads. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

38 11roxy_nash, tony_orlando, Dr.NephBHM_UK and 35 others
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mike.trainer_LA
Senior Member
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Los Angeles, CA
Jul 11, 2025 at 8:42 AM#13
Dr.ReproEndo said:
Liver enzyme update related to liver and MASH: I had mildly elevated ALT/AST at baseline (likely NAFLD).

I read this differently from Dr.ReproEndo, on substance rather than tone. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

Last edited: Jul 11, 2025 at 12:42 PM
39 12mia_MS2, LeilaHI, marcus_mpls and 36 others
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labquiet_amy
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Jul 12, 2025 at 10:23 PM#14

Adding the numbers, since they settle part of this. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

Correct me if the detail matters more than I have assumed.

Last edited: Jul 13, 2025 at 12:23 AM
40 13bri_stats, pete_manc_UK, anna.melb_AU and 37 others
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mike_mod
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Jul 14, 2025 at 12:03 PM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out. Report rather than reply if it drifts again.

41 14PurityPaulOR, MaxMetOK, MounjBrad and 38 others
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