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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMASH / Liver DiseaseMASH resolution without worsening fibrosis — looking for input Page 5

MASH resolution without worsening fibrosis — looking for input

PeptideSynthNJ Wed, Jul 2, 2025 at 8:50 AM 40 replies 1,673 viewsPage 5 of 8
bri_stats
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Jul 23, 2025 at 9:29 PM#21
raj_cambridge said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

No disagreement, though the timescale matters more than the mechanism here. Most of what looks like a difference in kind turns out to be a difference in how long somebody waited.

Last edited: Jul 24, 2025 at 1:29 AM
18 16sarah_nash92, FitDadDave, RunnerRach and 15 others
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Dr.RaviCardio
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Jul 30, 2025 at 1:57 PM#22
raj_cambridge said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Bookmarking. The distinction being drawn above is the one nobody else makes. Taking it to my next appointment.

Last edited: Jul 30, 2025 at 2:57 PM
19 17anna.melb_AU, mark_tokyo, hans_munich and 16 others
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Dr.RheumBOS
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Aug 6, 2025 at 6:21 AM#23

Clinical perspective, offered as context rather than as advice. Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third retelling.

20 18cory_ATX, lori_vegas, Dr.PulmRoch and 17 others
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DadBodDave
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Aug 12, 2025 at 10:41 PM#24
Dr.RheumBOS said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

This is my experience too, for whatever a second data point is worth.

21 19Dr.GastroMayo, JakeBK_lifts, DerekSJ_a1c and 18 others
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Dr.PulmRoch
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Aug 19, 2025 at 2:57 PM#25
Dr.RheumBOS said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

There is a second half to this that has not been said yet. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

Last edited: Aug 19, 2025 at 3:57 PM
22 20KristenIndy, MarkLI_maint, Dr.PeteFamMed and 19 others
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