Dr.PeteFamMed said:

For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

Dr.PeteFamMed said:

For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.

Dr.PeteFamMed said:

For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

Thank you — that is the clearest version of this I have read, and I have read a lot of them.

Adding the clinical framing, because it changes how the question reads. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

Reporting back.

Update. I did go to 2.4mg in the end, and the honest report is that it bought me less than the step before it and cost me two bad weeks. Worth knowing rather than worth repeating.