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ForumsSide Effects & ManagementDiarrhea vs constipation on GLP-1 — need advice Page 3

Diarrhea vs constipation on GLP-1 — need advice

BenResearch_OR Sat, Mar 15, 2025 at 9:12 PM 50 replies 2,016 viewsPage 3 of 10
DanielChem_CHI
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Mar 17, 2025 at 8:52 PM#11
Dr.MetabolicMD said:
Acid reflux and constipation: I developed GERD symptoms around week 6 that I'd never had before.

Drug interaction alert relevant to constipation: if you take oral levothyroxine (Synthroid), GLP-1 agonists can reduce absorption due to delayed gastric emptying. My TSH drifted up after starting semaglutide.

Solution: take levothyroxine on an empty stomach, 60 minutes before any food, and have your TSH rechecked 6-8 weeks after starting or changing GLP-1 dose. My endo had to increase my Synthroid by 12.5mcg.

48 21fiona_VT, denise_HTX, raj_cambridge and 45 others
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rachel_ABQ
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Mar 18, 2025 at 2:38 AM#12
VendorMark said:
Sulfur burps on constipation — the most underrated side effect nobody warned me about.

This is exactly what I could not find anywhere else. Printing the relevant bit and taking it with me.

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tony_orlando
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Orlando, FL
Mar 18, 2025 at 8:23 AM#13
Dr.MetabolicMD said:
Acid reflux and constipation: I developed GERD symptoms around week 6 that I'd never had before.

Gastroparesis symptoms with constipation: the delayed gastric emptying from GLP-1 agonists can cause early satiety, bloating, and feeling "full" for hours after a small meal.

Tips: eat your protein FIRST (most important macro), then vegetables, then carbs last. Chew thoroughly — 20-30 chews per bite isn't excessive. Avoid carbonated beverages with meals. If symptoms are severe, your doctor may recommend a gastric emptying study.

50 23ZaraB_AL, JakeSmashed95, NauseaFreeNow and 47 others
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FDA_TrackerJim
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Mar 18, 2025 at 2:08 PM#14

The figures, for anyone assembling their own picture. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.

1 24Dr.LeslieOBGYN
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Admin
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Mar 18, 2025 at 7:53 PM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out. Report rather than reply if it drifts again.

2 0PeptideSynthNJ, Dr.KarenChen
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