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ForumsSide Effects & ManagementDiarrhea vs constipation on GLP-1 — need advice

Diarrhea vs constipation on GLP-1 — need advice

BenResearch_OR Sat, Mar 15, 2025 at 9:12 PM 50 replies 2,016 viewsPage 1 of 10
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BenResearch_OR
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Mar 15, 2025 at 9:12 PM#1

Constipation replaced nausea at around week five and has been the more persistent of the two by a wide margin.

What I am after is whether fiber actually helps GLP-1 constipation or whether the evidence is borrowed from a different population.

I would rather have one careful answer than five confident ones.

17 12julia.endo, JessicaM_2024, TomFromTexas and 14 others
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PurityPaulOR
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Mar 15, 2025 at 9:55 PM#2

This one has a reasonably settled answer, so here it is. Fiber trials in this population are thin, and most of what gets quoted is extrapolated from idiopathic constipation in people eating normally. The extrapolation is not unreasonable but it is an extrapolation, and it fails specifically for insoluble fiber at low intake — the case that comes up here most often.

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VendorMark
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Mar 15, 2025 at 10:38 PM#3
PurityPaulOR said:
Fiber trials in this population are thin, and most of what gets quoted is extrapolated from idiopathic constipation in people eating normally.

Sulfur burps on constipation — the most underrated side effect nobody warned me about. 🤢 The smell is absolutely vile and comes on without warning.

What finally helped: taking a digestive enzyme supplement. Also, eating smaller portions and chewing thoroughly reduces the gas production.

If sulfur burps persist beyond 2-3 weeks, talk to your provider — it could indicate gastroparesis that needs medical attention.

Last edited: Mar 16, 2025 at 12:38 AM
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zoe_NC
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Mar 15, 2025 at 11:21 PM#4
BenResearch_OR said:
Constipation replaced nausea at around week five and has been the more persistent of the two by a wide margin.

This matches mine closely enough to be worth saying so. The mechanism is slowed transit plus reduced intake, and that combination determines which interventions work. Less food means less bulk, slower motility means more water reabsorbed, and the result is a smaller, drier, slower stool. Insoluble fiber adds bulk to a system that is already moving slowly, which is why it frequently makes things worse. Soluble fiber holds water and is the better first choice, and an osmotic agent works with the mechanism rather than against it.

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Dr.RenalNash
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Mar 16, 2025 at 3:24 AM#5

Adding the clinical framing, because it changes how the question reads.

Heartburn management on constipation: Pepcid (famotidine) 20mg has been my savior. The delayed gastric emptying means stomach acid just sits there.

Don't ignore persistent heartburn — chronic acid exposure can damage your esophagus. If OTC remedies aren't cutting it after 2 weeks, see your doctor for something stronger. You shouldn't suffer through this.

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