Dr.SurgeonPGH said:

pete_manc_UK said: ...regarding food noise mechanism of action...

Central vs peripheral GLP-1R signaling in food noise: elegant studies using brain-penetrant vs peripherally-restricted GLP-1 agonists show that ~80% of the weight loss effect is centrally mediated[1].

The key brain regions: arcuate nucleus (appetite), area postrema (nausea), NTS (satiety), VTA/NAc (reward). Peripheral effects (gastric emptying, insulin secretion) contribute but are secondary for weight loss.

This has implications for next-gen drugs: optimizing brain penetration and CNS receptor occupancy may be more important than systemic exposure.

FranDenver said:

Neuroscience perspective on food noise: GLP-1 receptors are expressed throughout the CNS, with high density in the hypothalamic arcuate nucleus, area…

This is exactly what I could not find anywhere else. I will report back once I have actually tried it.

Dr.SurgeonPGH said:

pete_manc_UK said: ...regarding food noise mechanism of action...

I read this differently from Dr.SurgeonPGH, on substance rather than tone. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

Adding the numbers, since they settle part of this. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

Moderator note: the sourcing question belongs in the vendor section and has been split out. Tagging this one for the weekly digest.