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ForumsCardiovascular OutcomesHas anyone dealt with apob reduction on tirzepatide? Page 3

Has anyone dealt with apob reduction on tirzepatide?

tampaLisa73 Sat, Apr 26, 2025 at 11:05 AM 41 replies 2,416 viewsPage 3 of 9
NurseKim_ATL
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Apr 30, 2025 at 10:26 PM#11
traveltech_sara said:
ApoB is the more informative number and it is cheap.

Agreed, and hsCRP is worth reading alongside them. The inflammatory-marker fall is often the most striking change on a panel and it is consistent with the cardiovascular outcome data.

6 4denise_HTX, raj_cambridge, ingrid_STO and 3 others
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BiostatsBrad
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May 2, 2025 at 11:30 PM#12
DanielChem_CHI said:
True, though the ladder is longer and that is not a neutral detail — six dose steps means six opportunities to stall on the way up, and plenty of…

This answered a question I did not know how to ask. Sending this to two other people who asked me the same thing last week.

7 5Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 4 others
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COA_Karl
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May 5, 2025 at 12:35 AM#13
traveltech_sara said:
ApoB is the more informative number and it is cheap.

Careful with treating an unchanged LDL-C as a failure. If ApoB and triglycerides both fell, the particle picture improved regardless of what the calculated LDL says.

Ask again with the specifics and you will get a better answer than this one.

8 6hyun_seoul, jim_asheville, matt_MKE and 5 others
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bri_stats
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May 7, 2025 at 1:41 AM#14

Adding the numbers, since they settle part of this. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

Worth separating that from the lipid panel, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

Last edited: May 7, 2025 at 5:41 AM
9 7JessicaM_2024, TomFromTexas, mike.trainer_LA and 6 others
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mike_mod
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May 9, 2025 at 2:48 AM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out. Report rather than reply if it drifts again.

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