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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCardiovascular OutcomesHas anyone dealt with apob reduction on tirzepatide? Page 4

Has anyone dealt with apob reduction on tirzepatide?

tampaLisa73 Sat, Apr 26, 2025 at 11:05 AM 41 replies 2,416 viewsPage 4 of 9
Dr.GutHealth
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May 11, 2025 at 3:56 AM#16

Clinical perspective, offered as context rather than as advice. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

11 9VanRx_Mike, steve_okc, dave_SLC and 8 others
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JennaRN
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May 13, 2025 at 5:05 AM#17
Dr.GutHealth said:
It is worth asking what the claim would look like if it were false.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

Ask again with the specifics and you will get a better answer than this one.

12 10PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 9 others
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EndoResFellow
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May 15, 2025 at 6:15 AM#18
Dr.GutHealth said:
It is worth asking what the claim would look like if it were false.

That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.

Last edited: May 15, 2025 at 8:15 AM
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BrianDallas92
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May 17, 2025 at 7:27 AM#19
Dr.GutHealth said:
It is worth asking what the claim would look like if it were false.

Saving this. It is the first explanation that did not require me to already understand it.

14 12Dr.EndoEP, GraceAZ_72, carl_compliance and 11 others
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Admin
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May 19, 2025 at 8:40 AM#20

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. Carry on.

36 9PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 33 others
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