Dr.LeslieOBGYN said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
Correct, and worth adding that it is reversible. Nothing being described here is a one-way door, which changes how cautious it is reasonable to be.
Dr.ReproEndo said:True, and anyone with reduced kidney function needs that target set by a clinician rather than a forum.
This is exactly what I could not find anywhere else.
Dr.LeslieOBGYN said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.
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Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Tagging this one for the weekly digest.